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8 Years
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| Brand Name : | complex |
| Model Number : | BGH-216 |
| Certification : | ISO9001/Halal/Kosher |
| Price : | US$380-382/kg |
| Payment Terms : | L/C, D/A, D/P, T/T, Western Union, MoneyGram |
| Supply Ability : | 5000000kg per year |
| Delivery Time : | 3 workdays after payment |
free sample birch bark extract betulin for anti-inflammatory
product details
Product name:Birch Bark Extract
Extract source: Betula Platyphylla L
Specification: Betulin 70%, 80%, 90%, 98%
Active ingredient:Betulin
Used Part:bark
Specification: 98%
CAS NO. : 473-98-3
Molar mass: 442.7
Appearance:White Powder
Flavor: Characteristic taste
Particle Size:80% pass through 80 mesh sieve
Test mothed: HPLC
Molecular formula:C30H50O2
Extract Solvent: Ethanol & Water
Solubility: Not Soluble in water, lightly soluble in ethanol
Usage: Pharmaceuticals, healthcares,and cosmetics
Product Description
Betulin, a non-bioactive precursor of betulinic acid, is also found
in the bark of the Betula alba (white birch) tree at concentrations
of up to 25%. The tree is fast-growing and abundant in North
America and Europe. The raw material is readily available in large
quantities since birch bark is considered a waste product in the
pulp and paper, and furniture manufacturing industries.
Betulin (lup-20(29)-ene-3β,28-diol) is an abundant, naturally
occurring triterpene. It is commonly isolated from the bark of birch trees and forms up to 30% of the dry weight of the extractive.The
purpose of the compound in the bark is not known. It can be
converted to betulinic
acid (the alcohol group replaced by a carboxylic
acid group), which is biologically more active than betulin itself.
Product Analysis
| Item | Specification | Result | Method |
| BasicProduct Information | |||
| Product name | betulin | ||
| Part of the Plant | bark | Conform | / |
| Country of Origin | China | Conform | / |
| Organoleptic Data | |||
| Appearance | Fine powder | Conform | NLS-QCS-1008 |
| Color | White powder | Conform | GB/T 5492-2008 |
| Odor& Taste | Characteristic | Conform | GB/T 5492-2008 |
| Process Data | |||
| Solvent(s) Used | Water and ethyl alcohol | Conform | / |
| Extract ration | / | Conform | |
| Content | Paeoniflorin≥98% | 98.18 | |
| Drying Method | Spray drying | Conform | / |
| Excipient | Maltodextrin | Conform | / |
| Physical Characteristics | |||
| Particle Size (80 mesh) | 98.0%pass 80mesh | Conform | GB/T 5507-2008 |
| Moisture | <5.0% | 2.8% | GB/T 14769-1993 |
| Ash Content | <4.0% | 1.4% | AOAC 942.05, 18th |
| Solvent Residue | Eur. Pharm | Conform | NLS-QCS-1007 |
| Heavy Metals | |||
| Total Heavy Metals | <10 ppm | Conform | USP <231>, method II |
| Arsenic | <1.0 ppm | Conform | AOAC 986.15, 18th |
| Lead | <1.0 ppm | Conform | AOAC 986.15, 18th |
| Mercury | <0.5 ppm | Conform | AOAC 971.21, 18th |
| Pesticide Residue | |||
| 666 | <0.2ppm | Conform | GB/T5009.19-1996 |
| DDT | <0.2ppm | Conform | GB/T5009.19-1996 |
| Microbiology | |||
| Total Plate Count | <1,000cfu/g | 17cfu/g | AOAC 990.12, 18th |
| Total Yeast & Mold | <100cfu/g | 3cfu/g | FDA (BAM) Chapter 18, 8th Ed. |
| E. Coli | Negative | Negative | AOAC 997.11, 18th |
| Salmonella | Negative | Negative | FDA (BAM) Chapter 5, 8th Ed. |
Product Function
Treatment of liver diseases is directed, mainly, to protecting
cells of the liver from the damages caused by different chemical
substances. Together with the radiation therapy and the surgery, in
the therapy of the tumor pathology, the important component of
treatment and rehabilitation of patients appears to be application
of medicinal plants. The unique biological activity of the
substances of those isolated by white part of birch bark
contributes to the decrease of toxic action of chemo- and radiation
therapy on the organism
The antioxidant activity of betuline is connected with its direct
effect on the ferments of the antioxidant protection, whose basic
functional role consists of the decomposition of organic peroxides,
first of all - peroxides of lipids, which play paramount role in
the disturbance of the normal structure of biological membranes.
Substances forming betulin possess the high gepatoprotektornoy and
detoxifying activity, inducing the ferments of the rendering safe
system of the liver, it normalizes bile secretion, reduces
cholesterol level in the blood
3.Betulin contains betulinic acid, which possesses a wide spectrum
of biological and pharmacological activities. Betulinic acid has
antimalarial and anti-inflammatory activities. Betulinic acid and
its derivatives have especially shown anti-HIV activity and
cytotoxicity against a variety of tumor cell lines comparable to
some clinically used drugs. A new mechanism of action has been
confirmed for some of the most promising anti-HIV derivatives,
which makes them potentially useful additives to the current
anti-HIV therapy. Betulinic acid is specifically cytotoxic to
several tumor cell lines by inducing apoptosis in cells. Moreover,
it is non-toxic up to 500 mg/kg body weight in mice. The literature
concerning derivatization of betulin for structure-activity
relationship (SAR) studies and its pharmacological properties is
reviewed.
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