health care product nutrition supplement breviscapine with best price
product details

Product name:Erigeron breviscapus Extract

Extract source:Bergenia purpurascens.
Specification:98%

Active ingredient:Breviscapine

Used Part:flower

CAS NO. : 116122-36-2

Molecular formula :C21H18O12

Molecular weight:462.4

Appearance:light yellow Powder

Flavor: Characteristic taste

Particle Size:80% pass through 80 mesh sieve

Test mothed: HPLC

Extract Solvent: Ethanol & Water

Solubility: Soluble in water, ethanol

Usage: Pharmaceuticals, healthcares,and cosmetics

Product Description
Breviscapine is a mixture of flavonoid glycosides extracted from the Chinese herbs. Previous studies have shown that breviscapine possesses comprehensive pharmacological functions. However, very little is known about whether breviscapine have protective role on cardiac hypertrophy. The aim of the present study was to determine whether breviscapine attenuates cardiac hypertrophy induced by angiotensin II (Ang II) in cultured neonatal rat cardiac myocytes in vitro and pressure-overload-induced cardiac hypertrophy in mice in vivo. Our data demonstrated that breviscapine (2.5-15 microM) dose-dependently blocked cardiac hypertrophy induced by Ang II (1 microM) in vitro. The results further revealed that breviscapine (50 mg/kg/day) prevented cardiac hypertrophy induced by aortic banding as assessed by heart weight/body weight and lung weight/body weight ratios, echocardiographic parameters, and gene expression of hypertrophic markers. The inhibitory effect of breviscapine on cardiac hypertrophy is mediated by disrupting PKC-alpha-dependent ERK1/2 and PI3K/AKT signaling. Further studies showed that breviscapine inhibited inflammation by blocking NF-kappaB signaling, and attenuated fibrosis and collagen synthesis through abrogating Smad2/3 signaling. Therefore, these findings indicate that breviscapine, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of PKC-alpha-dependent signaling.

Product Analysis

Product Function

Complex Nature Biotechnology CO., LTD. is specialized in R&D and production the effective chemical composition from natural biological. Depends on the rich resourse of Chinese herbal medicine in the shaanxi qinba mountains and the Strong Research Capability of universities in xi’an，custom and market oriented, Customize variety natural products and fine chemical products which meet the demands of the customers and the market.

We have 30 employees, especially 18 of them are senior or medium grade technicians, 5 of them are licensed pharmacists (Chinese traditional medicine),etc.Set up the joint lab with xi 'an jiaotong university, northwest university, xi 'an university of science and technology, xi 'an university of technology and other colleges.

We have 2 standard factory ,including 4 standard production line, 2 pilot production line , 1 GMP standard workshop and the independent testing and R&D center.We also equipped advanced detection and experimental apparatus such as gaseous phase、 iquid phase、ultrasound etc.

The main natural products active products includes all kinds of fruit and vegetable powder, chinese herbal medcine powder, nuts powder and mushroom powder etc.